Casanova, V., Sousa, F.H., Svoboda, P., Buch, C., D’Acremont, M., Christophorou, M.A., Pohl, J., Stevens, C. and Barlow, P.G. (2020a) Citrullination alters the antiviral and immunomodulatory activities of the human cathelicidin LL-37 during rhinovirus infection. Frontiers in Immunology. 11:85.
Hooper, K.M., Casanova, V., Kemp, S., Staines, K.A., Satsangi, J., Barlow, P.G., Henderson, P. and Stevens, C. (2019c) The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK. Inflammatory Bowel Diseases. 25(9): 1481-1496. (PubMed)
Biskou, O., Casanova, V., Hooper, K.M., Kemp, S., Wright, G.P., Satsangi, J., Barlow, P.G. and Stevens, C. (2019b) The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy. PLoS One. 14(1): e0209665. (PubMed)
Hooper, K.M. Barlow, P.G., Henderson, P. and Stevens, C. (2019a) Interactions between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease. Inflammatory Bowel Diseases. (PubMed)
Casanova, V. Sousa, F.H., Stevens, C. and Barlow, P.G. (2018) Antiviral therapeutic approaches for human rhinovirus infections. Future Virology. 13(7) 505-518. (PubMed)
Findlay, F., Pohl, J., Svoboda, P., Shakamuri, P., McLean, K., Inglis, N.F., Proudfoot, L. and Barlow, P.G. (2017c) Carbon nanoparticles inhibit the antimicrobial activities of the human cathelicidin LL-37 through structural alteration. Journal of Immunology. (PubMed)
Sousa, F.H., Casanova, V., Findlay, F., Stevens, C., Svoboda, P., Pohl, J., Proudfoot, L. and Barlow, P.G. (2017b) Cathelicidins display conserved direct antiviral activity towards rhinovirus. Peptides. 95. 76-83. (PubMed)
Hooper, K.M., Barlow, P.G., Stevens, C. and Henderson, P. (2017a) Inflammatory bowel disease drugs: a focus on autophagy. Journal of Crohn’s and Colitis. 11(1). 118-127 (PubMed)
Coyle, C., Wheelhouse, N., Jacques, M., Longbottom, D., Svoboda, P., Pohl, J., Duncan, W.C., Rae, M.T. and Barlow, P.G. (2016d) Ovine trophoblasts express cathelicidin host defence peptide in response to infection. Journal of Reproductive Immunology. 117:10-16. (PubMed)
Findlay, F., Proudfoot, L., Stevens, C. and Barlow, P.G. (2016c) Cationic host defence peptides; Novel antimicrobial therapeutics against Category A pathogens and emerging infections. Pathogens and Global Health. Jun 17: 1-11. (PubMed)
Henderson Sousa, F., Casanova, V., Stevens, C. and Barlow, P.G. (2016b) Antiviral host defense peptides. In Host Defence Peptides and Their Potential As Therapeutic Agents. R.M. Epand (Ed) Springer-Verlag Inc, Heidelberg. (Publisher Link)
Storrie, S., Longbottom, D., Barlow, P.G. and Wheelhouse, N. (2016a) MAPK activation is essential for Waddlia chondrophila induced CXCL8 expression in human epithelial cells. PLoS One. 11(3):e0152193. (PubMed)
Wheelhouse, N., Coyle, C., Barlow, P.G., Mitchell, S., Greub, G., Baszler, T., Rae, M.T. and Longbottom, D. (2014b) Waddlia chondrophila infects and multiplies in ovine trophoblast cells stimulating an inflammatory response. PLoS One. 9(7): e102386. (PubMed)
Barlow, P.G., Findlay, E.G., Currie, S.M. and Davidson, D.J. (2014a) Antiviral potential of cathelicidins. Future Microbiology. 9:55-73. (PubMed)
Barlow, P.G., Svoboda, P., Mackellar, A., Nash, A.A., York, I.A., Pohl, J., Davidson, D.J. and Donis, R.O. (2011) Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37. PLoS One. 6(10): e25333. (PubMed)
Song, J.M., Kim, Y.C., Barlow, P.G., Park, K.M., Donis, R.O., Prausnitz, M.R., Compans, R.W. and Kang, S.M. (2010d) Improved protection against avian influenza H5N1 virus by a single microneedle skin vaccination with virus-like particles. Antiviral Research. 88(2): 244-247. (PubMed)
Steitz, J., Barlow, P.G., Hossain, J., Kim, E., Okada, K., Kenniston, T., Rea, S., Lipatov, A.S., Donis, R. and Gambotto, A. (2010c) A candidate H1N1 pandemic influenza vaccine elicits protective immunity in mice. PLoS One. 5(5): e10492. (PubMed)
Barlow, P.G., Beaumont, P.E., Cosseau, C., Mackellar, A., Wilkinson, T.S., Hancock, R.E.W., Haslett, C., Govan, J.R.W., Simpson, A.J. and Davidson, D.J. (2010b) The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium. American Journal of Respiratory Cell and Molecular Biology 43(6): 692-702. (PubMed)
Fox, S., Wilkinson, T.S., Wheatley, P.S., Xiao, B., Morris, R.E., Sutherland, A., Simpson, A.J., Barlow, P.G., Butler, A.R., Megson, I.L. and Rossi, A.G. (2010a) NO-loaded Zn2+-exchanged zeolite materials; a potential bi-functional anti-bacterial strategy in medical device coatings. Acta Biomaterialia, 6(4), 1515-1521. (PubMed)
Li, H.L., Barlow, P.G., Bylund, J., Bjorstad, A., Mackellar, A., Conlon, J., Hiemstra, P., Haslett, C., Simpson, A.J., Rossi, A.G., and Davidson, D.J. (2009) Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not pro-inflammatory to phagocytosing macrophages. Journal of Leukocyte Biology. 86(4), 891-902. (PubMed)
Barlow, P.G., Brown, D.M., Donaldson, K., MacCallum, J. and Stone, V. (2008) Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure. Cell Biology and Toxicology. 24(3), 243-252. (PubMed)
Wilson, M.R., Foucaud, L.,Barlow, P.G., Hutchison, G.R., Sales, J., Simpson, R., and Stone, V. (2007) Nanoparticle interactions with zinc and iron: implications for toxicology and inflammation. Toxicology and Applied Pharmacology. 225(1). 80-89. (PubMed)
Barlow, P.G., Li, Y., Wilkinson, T.S., Bowdish, D.M.E., Lau, Y.E., Cosseau, C., Haslett, C., Simpson, A.J., Hancock, R.E.W. and Davidson, D.J. (2006b) The human cationic host defence peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system. Journal of Leukocyte Biology. 80(3). 509-520. (PubMed)
Stone, V., Barlow, P.G., Hutchison, G.R. and Brown, D.M. (2006a) Pro-inflammatory effects of particles on macrophages and epithelial cells. In Particle Toxicology. Donaldson, K and Borm, P.J.A. (eds). Taylor & Francis Publications.
Barlow, P.G., Clouter-Baker, A., Donaldson, K., MacCallum, J. and Stone, V. (2005c) Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages. Particle and Fibre Toxicology 2:11. (PubMed)
Barlow, P.G., Donaldson, K., MacCallum, J., Clouter, A. and Stone, V. (2005b) Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration. Toxicology Letters 155(3) 397-401. (PubMed)
Wilson, M.R., Barlow, P.G., Hutchison, G.R., Guy, K. Griffiths, A., Simpson, R.J. and Stone, V. (2005a) Nanoparticle and metal interactions and their impact on lung toxicology. W22 48-50. IEH Proc 9th Annual Review of Air Pollution Research.
Stone, V., Brown, D.M., Hutchison, G., Barlow, P.G., Lightbody, J., Tran, C. L., Heal, M., Hibbs, L., and Donaldson, K. (2004). Pro-inflammatory interactions between particles, metals and lung cells. INIS Monograph, 9th International Inhalation Symposium. 245-258.
Invited Public Interest Articles
- “Can you die from a common cold?” December 23, 2019. The Conversation.
- “’Missing emissions’ aren’t counted as pollution but could help kill you” September 26, 2018. The Conversation.
- “We have a good chance of curing the common cold in next ten years – a scientist explains” 18 June 2018. The Conversation
- “Zika has crossed the Rio Grande … now what?” 30 November 2016. The Converation
- “Why Glasgow Ebola case is very unlikely to spread” 29 December 2014. The Conversation.
- “New 15-minute saliva test for Ebola may be big boost in the fight against outbreak”. 2 December 2014. The Conversation
- “Bird flu is back, but should we be worried?”. 17 November 2014. The Conversation
- “Ebola won’t gain a foothold in Western countries – here’s why”. 8 October 2014. The Conversation.
Recent Meetings & Presentations:
Barlow, P.G. (2019) The role of host defence peptides in dengue virus and rhinovirus infection. The University of Indonesia (Invited Presentation), Jakarta, Indonesia.
Barlow, P.G. (2019) Host defence peptides as novel antiviral therapeutics. The Eijkman Institute for Molecular Biology (Invited Presentation), Jakarta, Indonesia.
Barlow, P.G. (2018) A Pep Talk: Curing The Common Cold. The Royal Scottish Society of Arts (RSSA) Invited Public Lecture.
Casanova, V., Henderson Sousa, F., Stevens, C. and Barlow, P.G. (2018) Modulation of autophagy and inflammation in rhinovirus infection. Edinburgh Immunology Group Annual Symposium (Invited Presentation). Edinburgh, UK.
Casanova, V., Henderson Sousa, F., Stevens, C. and Barlow, P.G. (2018) Host defence peptides in rhinovirus infection. Edinburgh Infectious Diseases Annual Symposium (Invited Presentation). Edinburgh, UK.
Barlow, P.G. (2018) Can we ever cure the common cold? Edinburgh International Science Festival, Hosted by Edinburgh Skeptics (Invited Presentation).
Hooper, K., Barlow, P.G., Henderson, P. and Stevens, C. (2018) Azathioprine modulates autophagy and the ER-stress/unfolded protein response. 13th Congress of European Crohn’s and Colitis Organisation / Inflammatory Bowel Diseases. Vienna, Austria.
Casanova, V., Henderson Sousa, F., Pohl, J., Svoboda, P., Stevens, C. and Barlow, P.G. (2017) Post-translation modification of host defence peptides in rhinovirus infection disrupts antiviral activity. British Society for Immunology Annual Congress 2017. Brighton, U.K.
Barlow, P.G. (2017) Engaging with media: An Immunologist’s perspective. British Society for Immunology Annual Congress 2017. Brighton, U.K.
Henderson Sousa, F., Stevens, C., Casanova, V., Findlay, F., Pohl, J., Svoboda, P. and Barlow, P.G. (2017) Cationic host defence peptides as novel therapeutics for rhinovirus infection. Gordon Research Conference on Antimicrobial Peptides 2017. Ventura, California, USA.
Hooper, K., Barlow, P.G., Henderson, P. and Stevens, C. (2017) An investigation of azathioprine on autophagy pathway activity. British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) 2017 Annual Meeting. Glasgow, U.K.
Hooper, K., Barlow, P.G., Henderson, P. and Stevens, C. (2017) An investigation of azathioprine on autophagy pathway activity. 12th Congress of the European Crohns and Colitis Organisation. Barcelona, U.K.
– Winner Best Poster
Henderson Sousa, F., Casanova, V., Stevens, C., Stainsby, F., Pohl, J., Svoboda, P. and Barlow, P.G. (2016) Cathelicidins as a novel therapeutic for rhinovirus infection. British Society for Immunology / NVVI Annual Congress 2016, Liverpool, U.K.
Casanova, V., Henderson Sousa, F., Stevens, C. and Barlow, P.G. (2016) Modulation of endogenous LL-37 as an antiviral strategy against human rhinovirus. British Society for Immunology / NVVI Annual Congress 2016, Liverpool, U.K.
Shepherd, S.F., Barlow, P.G., Pohl, J., Svoboda, P. and Stevens, C. (2016) The role of host defence peptides in Vitamin D stimulated autophagy: Potential therapeutic benefits for Crohn’s Disease patients. British Society for Immunology / NVVI Annual Congress 2016, Liverpool, U.K.
Casanova, V., Henderson Sousa, F., Stevens, C. and Barlow, P.G. (2016) Modulation of endogenous LL-37 as an antiviral strategy against human rhinovirus. Edinburgh Infectious Diseases Annual Symposium. Edinburgh, UK.
Henderson Sousa, F., Stevens, C., Casanova, V,. Findlay, F., Stainsby, F., Pohl, J., Svoboda, P. and Barlow, P.G. (2016) Cationic Host Defence Peptides as novel therapeutics for rhinovirus and influenza virus infection. Edinburgh Infectious Diseases Annual Symposium. Edinburgh, UK.
– Winner Best Poster
Wheelhouse, N., Storrie, S., Vacca, F., Barlow, P.G., Rae, M. and Longbottom, D. (2015) Waddlia chondrophila stimulates CXCL8 expression in epithelial cells via p38 and p42/44 MAPK dependent pathways. The Third European Meeting on Animal Chlamydioses. Paris, France.
Wheelhouse, N., Storrie, S., Vacca, F., Barlow, P.G., Rae, M. and Longbottom, D. (2015) Waddlia chondrophila stimulates CXCL8 expression in epithelial cells via p38 and p42/44 MAPK dependent pathways. The Society for Reproduction and Fertility Annual Conference, Oxford, UK.
Wheelhouse, N., Storrie, S., Vacca, F., Barlow, P.G. and Longbottom, D. (2015) Waddlia chondrophila stimulates CXCL8 expression in epithelial cells via p38 and p42/44 MAPK dependent pathways. Edinburgh Infectious Diseases Annual Symposium, Edinburgh, UK.
Wheelhouse, N., Storrie, S., Vacca, F., Barlow, P.G. and Longbottom, D. (2015) Waddlia chondrophila stimulates CXCL8 expression in epithelial cells via p38 and p42/44 MAPK dependent pathways. The Society for General Microbiology Annual Conference, Birmingham, UK.
Findlay, F., Proudfoot, L., Svoboda, P., Pohl, J. and Barlow, P.G. (2014) The impact of nanomaterials on human host defence. British Society for Immunology Summer School 2014. Edinburgh, UK.
Findlay, F., Proudfoot, L., Svoboda, P., Pohl, J. and Barlow P.G. (2013) The antimicrobial activity of the cationic host defence peptide LL-37 is inhibited by exposure to nanomaterials. British Society for Immunology Congress. Liverpool, UK.
Findlay, F., Proudfoot, L., Svoboda, P., Pohl, J. and Barlow P.G. (2013) The impact of nanomaterials on human host defence. Scottish Toxicology Interest Group (STIG) Bi-annual Meeting, Glasgow, UK.
Logermann, S.M., Findlay, E.G., McHugh, B., Beaumont, P.E., Barlow, P.G., Mackellar, A., Gallo, R.L., Govan, J.R.W., Fitch, P.M., Schwarze, J. and Davidson, D.J. (2012) Cathelicidins enhance host defence against bacterial and viral lung infections via antimicrobial activity and induction of protective inflammation. Society of Leukocyte Biology 2012 Annual Meeting. Maui, Hawai’i.
Findlay, E.G., Logermann, S.M., Beaumont, P.E., Barlow, P.G., Mackellar, A., Gallo, R.L., Govan, J.R.W., Fitch, P.M., Schwarze, J. and Davidson, D.J. (2012) The role of cathelicidins in protection against pathogenic lung infections. European Congress of Immunology 2012, Glasgow, UK.
Dickson, C., Prach, M., Fraser, J., Ingram, L., Barlow, P.G., Hutchison, G.R., Proudfoot, L. and Malone, E.M. (2012) Modelling the impact of nanomaterial-mediated neutrophil activation. NanoImpactNet – QNano Conference, Dublin, Ireland
Beaumont, P.E., Barlow, P.G., Mackellar, A., MacKenzie, K., Svoboda, P., Nash, A.A., York, I.A., Pohl, J., Gallo, R.L., Donis, R.O., Govan, J.R.W. and Davidson, D.J. (2011) The host defence peptide LL-37 and murine orthologue mCRAMP are protective against pulmonary bacterial and viral infection in vivo. British Society for Immunology Annual Congress, Liverpool, UK
Li, H.N., Barlow, P.G., Bylund, J., Mackellar, A., Björstad, Å., Conlon, J., Hiemstra, P.S., Haslett, C., Gray, M., Simpson, A.J., Rossi, A.G., and Davidson, D.J.(2009) Secondary necrosis of apoptotic neutrophils induced by LL-37 has anti-inflammatory effects on macrophages. European Scientific Conference–Antimicrobial Peptides: New challenges for Science, UK
Li, H.N., Barlow, P.G., Bylund, J., Mackellar, A., Björstad, Å., Conlon, J., Hiemstra, P.S., Haslett, C., Gray, M., Simpson, A.J., Rossi, A.G., and Davidson, D.J.(2009) Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages. Tri-society annual meeting of the Society for Leukocyte Biology, International Cytokine Society, and International Society for Interferon and Cytokine Research, Lisbon, Portugal.
Barlow, P.G., Beaumont, P.E., Cosseau, C., Wilkinson, T.S., Simpson, A.J., Hancock, R.E.W., Govan, J.R.W., Haslett, C. and Davidson, D.J., (2008) The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium via mitochondrial membrane permeabilisation. Inflammation in Bacterial & Viral Infection Conference. Edinburgh, UK
– Winner Best Invited Presentation
Li, H.N., Barlow, P.G., Bylund, J., Bjorstad, A., Hiemstra, P.S., Haslett, C., Simpson, A.J., Rossi, A.G., and Davidson, D.J. (2008) The human cationic host defence peptide LL-37 modulates cell death in human neutrophils. 10th Biennial Meeting of the International Endotoxin and Innate Immunity Society. Edinburgh, UK
Li, H.N., Barlow, P.G., Haslett, C., Rossi, A.G., and Davidson, D.J. (2007) The human cationic host defence peptide LL-37 modulates cell death pathways in human neutrophils. Scottish Immunology Group (BSI) Summer Meeting, St Andrews, UK
Barlow, P.G., Cosseau, C., Wilkinson, T.S., Simpson, A.J., Hancock, R.E.W., Haslett, C., and Davidson, D.J. (2007) Modulation of apoptosis by the cationic host defense peptide, LL-37, in an in vitro model of acute lung infection. American Thoracic Society (ATS) International Conference 2007, San Francisco, USA
Barlow, P.G., Cosseau, C., Wilkinson, T.S., Simpson, A.J., Hancock, R.E.W., Haslett, C., and Davidson, D.J. (2007) Innate immune modulation by the cationic host defence peptide, LL-37, in a model of acute lung infection. Death, Danger and Immunity, Pasteur Institute, Paris
Barlow, P.G., Li, Y., Wilkinson, T.S., Haslett, C., Simpson, A. J., Hancock, R. E. W., and Davidson, D. J. (2006) Divergent modulation of apoptotic pathways in primary human innate immune cells by the cationic host defence peptide LL-37. Scottish Society for Experimental Medicine meeting 2006, Edinburgh
Barlow, P.G., Li, Y., Wilkinson, T.S., Haslett, C., Simpson, A. J., Hancock, R. E. W., and Davidson, D. J. (2006) The cationic host defence peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary innate immune cells. 14th Euroconference on Apoptosis, Sardinia
Barlow, P.G., Li, Y., Wilkinson, T.S., Bowdish, D. M. E., Lau, Y. E., Cosseau, C., Haslett, C., Simpson, A. J., Hancock, R. E. W., and Davidson, D. J. (2006) LL-37 as a component of host defence in the lung: modulation of apoptotic pathways in human primary innate immune cells. Infections and Lung Disease, Pasteur Institute, Paris
